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吴鑫  

吴鑫,博士

研究兴趣:

以精原干细胞体外培养增殖及功能移植为平台,研究干细胞的自我更新,体外分化和去分化机制;研究雄性性腺内生殖细胞发育所需微环境的信号传导及转录调控;从雄性生殖干细胞角度发展转基因或基因纠正技术。

 

电话:025-86869506

E-mailxinwu@njmu.edu.cn

地址:南京医科大学学海楼


  


        吴鑫,男,2003年博士毕业于复旦大学;20052月至200612月在美国韦恩州立大学从事博士后研究;20071月至20121月在美国宾夕法尼亚大学从事博士后研究;现任南京医科大学教授,博士研究生导师; 生殖医学国家重点实验室,研究课题PI

科研资助:

国家自然科学面上基金编号:31571537,长链非编码RNA LncRNA033862在GDNF介导的精原干细胞自我更新中的作用2016.1-2019.12

国家自然科学面上基金编号:31271581,ETV5介导的小鼠精原干细胞自我更新转录调控机制研究 2013.1-2016.12

国家重大基础研究专项子课题(973)编号:2013CB945201,血脂紊乱影响精子发生和成熟过程的关键基因的调控机制 2013.5-2017.12


代表论文(*通讯作者):


1. Li L, Wang M, Wang M, Wu X, Geng L, Xue Y, Wei X, Jia Y, Wu X*. A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cells. Cell Death Dis. 2016 Mar 10;7:e2140. doi: 10.1038/cddis.2016.24

2. Xu J, Wan P, Wang M, Zhang J, Gao X, Hu B, Han J, Chen L, Sun K, Wu J, Wu X*, Huang X*, Chen J*. AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment. Cell Death Dis. 2015 Jul 16;6:e1818. doi: 10.1038/cddis.2015. 182.

3. Wu X, Goodyear SM, Abramowitz LK, Bartolomei MS, Tobias JW, Avarbock MR, Brinster RL. Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years. Hum Reprod. 2012 May;27(5):1249-59. doi: 10.1093/humrep/des077.

4. Wu X, Peppi M, Vengalil MJ, Maheras KJ, Southwood CM, Bradley M, Gow A. Transgene-mediated rescue of spermatogenesis in Cldn11-null mice. Biol Reprod. 2012 May 3;86(5):139, 1-11. doi: 10.1095/biolreprod.111.096230.

5. Wu X, Goodyear SM, Tobias JW, Avarbock MR, Brinster RL. Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice. Biol Reprod. 2011 Dec;85(6):1114-23. doi: 10.1095/biolreprod.111.091793.

6. Wu X, Oatley JM, Oatley MJ, Kaucher AV, Avarbock MR, Brinster RL. The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells. Biol Reprod. 2010 Jun;82(6):1103-11. doi: 10.1095/biolreprod.109.083097.

7. Wu X, Schmidt JA, Avarbock MR, Tobias JW, Carlson CA, Kolon TF, Ginsberg JP, Brinster RL Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21672-7. doi: 10.1073/pnas.0912432106.