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沈彬  

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沈彬,博士,研究员,博士生导师

生殖医学相关研究兴趣:

RNA表观修饰在配子发生的作用

 基因编辑和治疗

地址:南京医科大学学海楼B222

电话:025-86869382

E-mail:binshen@njmu.edu.cn



 

沈彬,男,1985年生,2008年获得兰州大学理学学士学位,2014年获得南京大学理学博士学位。现任南京医科大学生殖医学国家重点实验室研究员、南京医科大学特聘教授、博士生导师。获得2016年江苏省杰出青年基金和2017年国家优秀青年基金。致力于RNA表观修饰在配子发生过程中的生物学功能的研究,结合小鼠敲除模型,利用高通量测序、蛋白质组学技术与生物信息学,解析RNA表观修饰在配子发生过程中的调控网络;以及利用基因编辑技术,进行基因编辑和治疗。以第一作者/通讯作者在Cell 、Nature Methods等杂志发表论文20余篇,获得国家发明专利两项。

 

承担项目:

  1. 面上项目(31970796),RNA m6A甲基转移酶Kiaa1429在精子发生中的作用机制研究,2020.1-2023.1260万,项目负责人。

  2. 优秀青年科学基金(31622039),RNA m6A修饰与精子发生,2017.1-2019.12130万,项目负责人。

  3. 江苏省杰出青年基金(BK20160045),RNA m6A表观修饰在精子发生过程中的作用和机制研究2016.7-2019.6100万,项目负责人。

  4. 国家重点研发计划(2016YFC1000600),人类配子发生、成熟障碍与胚胎停育的分子机制,2016.7-2020.12180万,项目骨干。

  5. 面上项目(31571372),小SpyCas9的合理设计和优化,2016.1-2019.1265万,项目负责人。

  6. 南京医科大学引进人才启动经费(KY116RC011409),临床配子发生缺陷的相关SNP的功能注释及基因修复,2014.6-2016.6100万,项目负责人。

 

代表性论文*equal contribution, #corresponding author

  1. Qian Zhang, Fengcai Wen, Siqi Zhang, Jiachuan Jin, Lulu Bi, Ying Lu, Ming Li, Xu-Guang Xi, Xingxu Huang, Bin Shen#, and Bo Sun#. The post-PAM Interaction of RNA-guided spCas9 with DNA Dictates its Target Binding and Dissociation. Sci Adv. 2019 Nov 13;5(11):eaaw9807.

  2. Wang H, Zuo H, Liu J, Wen F, Gao Y, Zhu X, Liu B, Xiao F, Wang W, Huang G, Shen B#, Ju Z#. Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration. Cell Res. 2018 Agu;28(10):1035–1038.

  3. Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Sha J, Zhuang M, Huang X, Shen B#, Yang L#, Chen J#. APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nat Struct Mol Biol. 2018 Jan;25(1):45-52.

  4. Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang X, Guerrero L, Xie P, He E, Shen B#, He C#. YTHDC1 Mediates Nuclear Export of N6-methyladenosine Methylated mRNAs. Elife. 2017 Oct 6;6. pii: e31311.

  5. Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B#, He C#. Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res. 2017 Sep;27(9):1115-1127.

  6. Yuan Y*, Zhou Q*, Wan H*, Shen B*, Wang X, Wang M, Feng C, Xie M, Gu T, Zhou T, Fu R, Huang X, Zhou Q, Sha J, Zhang XY. Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Res. 2015 Jul;25(7):851-63.

  7. Iyer V*, Shen B*, Zhang W, Hodgkins A, Keane T, Huang X, Skarnes WC. Off-target mutations are rare in Cas9-modified mice. Nat Methods. 2015 May 28;12(6):479.

  8. Chen Y*, Cui Y*, Shen B*, Niu Y*, Zhao X, Wang L, Wang J, Zhou Q, Ji W, Sha J, Huang X. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys. Cell Res. 2015 Feb;25(2):262-5.

  9. Shen B*, Zhang W*, Zhang J*, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods. 2014 Apr;11(4):399-402.

  10. Niu Y*, Shen B*, Cui Y*, Chen Y*, Wang J, Wang L, Kang Y, Zhao X, Si W, Xiang P, Zhou J, Huang X, Ji W, Sha J. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell. 2014 Feb 13;156(4):836-43. (Selected by Nature as one of the events in the years in sciences: Wins and Losses) (Selected by Cell as one of the 10 Best articles in 2014).

  11. Shen B*, Zhang J*, Wu H*, Wang J, Ma K, Li Z, Zhang X, Zhang P, Huang X. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res. 2013 May;23(5):720-3.