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叶岚  

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叶岚教授,博士生导师

主要研究兴趣:

代谢性疾病与雄性不育

配子发生机制

电话:025-86869509

E-maillanye@njmu.edu.cn

地址:南京医科大学学海楼

  


叶岚,女,1981年生。2009年于香港中文大学生物化学系博士学位,2009年-2013年美国宾夕法尼亚大学医学院糖尿病和代谢系博士后,主要从事研究信号通路、代谢性疾病与雄性不育的关联性以及乳腺癌疾病发病机制及其治疗。2013年南京医科大学生殖医学国家重点实验室教授。研究成果在Science,Aging,Front Genet和J Clin Invest等国际杂志上发表。


代表性论文(5篇)

1. Dudley W Lamming#,Lan Ye#,PekkaKatajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima, David A Guertin, David M Sabatini, Joseph A Baur: Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.Science, Mar 2012, 335(6076): 1638-43. (#共同第一作者)

2.Lan Ye, Anne L. Widlund, Carrie A. Sims, Dudley W. Lamming, Yuxia Guan, James G. Davis, David M. Sabatini, David E. Harrison, Ole Vang, and Joseph A. Baur: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.Aging (Albany NY), Jul 2013, 5(7):539-50.

3.Lan Ye,Behzad Varamini,Dudley W. Lamming,David M. Sabatini, andJoseph A. Baur: Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.Frontiers in Genetics, Sep 2012, 3:177.

4. Dudley W. Lamming,Lan Ye, David M. Sabatini, and Joseph A. Baur: Rapalogs and mTOR inhibitors as anti-aging therapeutics.J Clin Invest, 2013 Mar, 123(3):980-9.

5.Lan Ye, Wai M. Gho, Franky L. Chan, Shiuan Chen, Lai K. Leung. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.Int J Cancer, Mar 2009, 124(5):1028-36.