刘 妍，博士，教授，博士生导师
生殖医学相关研究兴趣：
1. 神经发育学
2. 干细胞再生医学
地 址：南京市江宁区龙眠大道101号至诚楼Y302
E-mail：yanliu@njmu.edu.cn
刘妍，南京医科大学药学院二级教授，博士生导师, 科技部重点研发专项首席科学家，国家杰出青年基金获得者，国家优秀青年基金获得者，首届江苏省青年女科学家，江苏省杰出青年基金获得者，入选江苏省双创人才、江苏省“333”工程培养对象、和六大人才高峰等。研究着重于利用人脑类器官开展神经疾病机制及细胞移植治疗研究，成果发表于Nature Biotechnology, Nature Communication, the Journal of Clinical Investigation, Molecular Psychiatry和EMBO Molecular Medicine等国际权威期刊；获得“江苏省巾帼科技之星”称号（2020），参与获得江苏省科技进步奖二等奖（2020）。担任中国神经科学学会理事，中国细胞生物学学会神经细胞生物学分会副会长，中国神经科学学会青年委员会委员，江苏省神经科学学会副理事长等职。
代表性论文
1. Xiao-Yan Tang, Lei Xu, Jingshen Wang, Yuan Hong, Yuanyuan Wang, Qian Zhu, Da Wang, Xin-Yue Zhang, Chun-Yue Liu, Kai-Heng Fang, Xiao Han, Shihua Wang, Xin Wang, Min Xu, Anita Bhattacharyya, Xing Guo*, Mingyan Lin*, Yan Liu*. Suppressing the DSCAM/PAK1 pathway reverses neurogenesis deficits in Down Syndrome patient iPSC-derived cerebral organoids. The Journal of Clinical Investigation, 2021 Jun 15;131(12):e135763. doi: 10.1172/JCI135763. (通讯作者)
2. Xin Dong, Shi-Bo Xu, Xin Chen, Mengdan Tao, Xiao-Yan Tang, Kai-Heng Fang, Min Xu, Yufeng Pan, Yuejun Chen, Shuijin He*, Yan Liu*. Human cerebral organoids establish subcortical projections in the mouse brain after transplantation. Molecular Psychiatry, 2021; 26(7): 2964–2976. (通讯作者)
3. Kaiqin Lu, Yuan Hong , Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang,Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo,* & Yan Liu*.Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C. EMBO MolecularMedicine. 2023 Jan 11;15(1):e16364. (通讯作者)
4. Chun-Yue Liu#, Zi-Xing Fu#, Shan-Shan Wu#, Xiao-Song Wang#, Sheng-Rong Zhang#, Chu Chu#, Yuan Hong, Wen-Bo Wu, Sheng-Qi Chen, Yue-Qing Jiang, Yang Wu, Yong-Bo Song, Yan Liu*, Xing Guo*. Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington’s disease. EMBO Molecular Medicine. 2022 Jul 7;14(7):e15851. (通讯作者)
5. Wanying Zhu, Mengdan Tao, Yuan Hong, Shanshan Wu, Chu Chu, Zhilong Zheng, Xiao Han, Qian Zhu, Min Xu, Andrew G Ewing*, Xing Guo* and Yan Liu*. Dysfunction of vesicular storage in young-onset Parkinson’s patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry.Chemical Science, 2022 May 11;13(21):6217-6223. (通讯作者)
6. Chun Ping Cui, Yuan Zhang, Chanjuan Wang, Fang Yuan, Hongchang Li, Yuying Yao , Yuhan Chen , Chunnan Li, Wenyi Wei , Cui Hua Liu, Fuchu He, Yan Liu*, Lingqiang Zhang*. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nature communication. (2018) 9:4648, DOI: 10.1038 (通讯作者)
7. Fang Yuan, Kai-Heng Fang, Yuan Hong, Shi-Bo Xu, Min Xu, Yufeng Pan, Yan Liu*. LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons. Protein & Cell. 2020. DOI: 10.1007/s13238-019-00686-6. (通讯作者)
8. Fang Yuan, Xin Chen, Kai-Heng Fang, Yuanyuan Wang, Mingyan Lin, Shi-Bo Xu, Hai-Qin Huo, Min Xu, Lixiang Ma , Yuejun Chen, Shuijin He* and Yan Liu* Induction of human SST and PV neurons by expressing a single transcription factor LHX6. eLIFE, 2018 Sep 25, DOI:10.7554/eLife.37382 (通讯作者)
9. Hai-Qin Huo#, Zhuang-yin Qu#, Fang Yuan, Lixiang M, Lin Yao, Min Xu, Yao Hu, Jing Ji,Anita Bhattacharyya, Su-Chun Zhang*, and Yan Liu*. Modeling Down syndrome with patient iPSCs reveals cellular and migration deficits of GABAergic neurons. Stem Cell Reports, 2018 Apr 10;10(4):1251-1266 (通讯作者)
10. Xiao-Yan Tang#, Shanshan Wu#, Da Wang, Chu Chu, Yuan Hong, Mengdan Tao, Hao Hu, Min Xu, Xing Guo*, Yan Liu*. “Human organoids in basic research and clinical applications.” Signal transduction and targeted therapy vol. 7,1 168. 24 May. 2022, doi:10.1038/s41392-022-01024-9.(通讯作者)
11. Yan Liu#, Huisheng Liu, Conall Farnen, Lin Yao, Su-Chun Zhang* (2013). Directed differentiation of cortical GABA interneurons from human pluripotent stem cells. Nature Protocol, Sep;8(9):1670-9. (第一作者)
12. Yan Liu#, Jason P. Weick, Huisheng Liu, Robert Krencik, Xiaoqing Zhang, Lixiang Ma, Su-Chun Zhang*. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology, 2013 May 21 (31) 440-447. (第一作者)
13. Marina E. Emborg#, Yan Liu#, Jiajie Xi, Xiaoqing Zhang, Yingnan Yin, Valerie Joers, Christine Swanson, James E. Holden, Su-Chun Zhang*. Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain. Cell Reports, 3: 646-650. （并列第一作者）
授权专利
Su-Chun Zhang, Yan Liu, Lixiang Ma. Directed differentiation of functional basal forebrain cholinergic neurons and striatal GABAergic projection neurons from primate stem cells. 美国专利号：US 8,895,302 B2，专利获批日期：2014年11月25日。
刘妍，曹诗颖，胡瑶，陈成，徐敏。诱导分化hPSCs 为谷氨酰胺能神经元的方法，授权号：201610300819.9，授权日期：2019年3月4日。
项目基金
1. 国家重点研发计划重点专项项目，2021YFA1101800，基于人源性干细胞移植的重大脑疾病神经环路重建研究，2021/12-2026/06，2380万，在研，首席
2. 国家自然科学基金杰出青年科学基金项目，82325015，人脑类器官与神经疾病，2024/01 -2028/12，400万，在研，主持
3. 国家自然科学基金优秀青年科学基金项目，81922022，干细胞神经分化及在神经系统疾病中的作用研究，2020/01 -2022/12，130万，结题，主持
4. 国家重点研发计划重点专项项目，2019YFA0802703，家族性高胆固醇血症发病新机制及其导致重要器官发育缺陷的研究，2019/12-2024/11，130.5万，在研，研究骨干
