About the researcher
Mingxi Liu.Dr received his B.M and Ph.D. from Nanjing Medical University. After post-doc training in Bernard Robaire’s lab at McGill University, he returned to Nanjing Medical University to started his independent research as an associate professor in State Key Laboratory of Reproductive Medicine and Offspring Health in 2014 and is currently in full professorship.
Dr. Liu ’s research interests are centered on understanding the functions of male infertility-related genes by gene knockout and proteomic techniques. He has successfully elucidated the functions of crucial complexes such as MIPs, N-DRC and RS in spermatogenesis. As a corresponding author, he has published over 30 papers in authoritative journals including Cell, PNAS, Cell Research, Nucleic Acids Research, Cell Reports, etc. Liu served as a reviewer for academic journals, such as PNAS, Nature Communications, Science Advances, etc. And he also participate in the Society for the Study of Reproduction (SSR) Publications Committee.
Email: mingxi.liu@njmu.edu.cn
Selective Publications
1. Major spliceosome defects cause male infertility and are associated with nonobstructiveazoospermia in humans. Wu H, Sun L, Wen Y, Liu Y, Yu J, Mao F, Wang Y, Tong C, Guo X, Hu Z, Sha J, Liu M*, Xia L*. ProcNatlAcadSci USA. 2016 Apr 12;113(15):4134-9.
2. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M*, Matzuk MM*, Liu M*.Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5370-E5378.
3.An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice. Zhang Y, Guo R, Cui Y, Zhu Z, Zhang Y, Wu H, Zheng B, Yue Q, Bai S, Zeng W, Guo X, Zhou Z, Shen B, Zheng K, Liu M*, Ye L*, Sha J*. Cell Res. 2017 Nov;27(11):1392-1396.
4.FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W*, Liu M*. Nucleic Acids Res. 2019 Nov 14. pii: gkz992. doi: 10.1093/nar/gkz992
5. Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Zhang X, Xiao Z, Zhang J, Xu C, Liu S, Cheng L, Zhou S, Zhao S, Zhang Y, Wu J, Wang Y*, Liu M*. Cell Rep. 2022 Nov 22;41(8):111683.
6. DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Zhou S, Yuan S, Zhang J, Meng L, Zhang X, Liu S, Lu G, Lin G, Liu M*, Tan YQ*. Signal Transduct Target Ther. 2023 Jan 10;8(1):26.
7. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M*, Gui M*, Wu J*. Cell. 2023 Jun 22;186(13):2897-2910
Grants
National Key Research and Development Program, Grant No. 2022YFC2702702 2022-2025
National Natural Science Foundation of China (General Program), Grant No. 32270899 2023-2026
National Natural Science Foundation of China (General Program), Grant No. 32070842 2021-2024
Science Foundation for Distinguished Young Scholars of Jiangsu Province, Grant No. BK20230004 2023-2026