刘明兮，男，博士，国家重大人才工程青年学者。2008年攻读南京医科大学生殖医学专业博士，师从沙家豪教授、周作民教授；2012年10月加入加拿大McGill University美国男科学会会长Bernard Robaire院士实验室从事博士后研究。人类精子计划发起人，解析生精细胞染色质重塑与头部变形的关键分子机制，揭示精子鞭毛轴丝组分、功能及其附属器组装核心机制：包括阐明轴丝亚组分N-DRC、RS在精子轴丝的新功能和作用机制，发现精子关键新细胞结构刘明兮囊泡（MXL Vesicles）和线粒体胶，发现并定义弱精子症的最大亚型MIVA。作为通讯作者（含共同）在《Cell》、《Nature Structural & Molecular Biology》、《PNAS》、《Nature Communications》、《Science Advances》、《Cell Research》、《Signal Transduction and Targeted Therapy》、《Science Bulletin》等权威期刊发表系列论文。2018-2021生殖研究学会（The Society for the Study of Reproduction,SSR）出版委员会成员（唯一中国成员）。担任《Biology of Reproduction》、《Journal of Reproduction and Development》编委。主持国家重点研发计划课题1项，国家自然科学基金面上项目5项、江苏省杰出青年基金1项，江苏省优秀青年基金1项，获2015年国家科技进步奖二等奖, 2021年全国妇幼健康科学技术奖自然科学奖一等奖。第七届全国大学生基础医学创新研究暨实验设计论坛最佳学术奖及全国大赛金奖指导教师。

科研资助：

国家自然科学基金委员会，面上项目，32470895，SCCPDH-CPT1B在精子线粒体鞘组装过程中的机制研究，2025.01-2028.12，50万，在研，主持

国家自然科学基金委员会，面上项目，32270899，精子发生中mRNA下游开放阅读框（downstream Open Reading Frame，dORF）的功能研究，2023.01-2026.12，54万，在研，主持

代表性论文：

1. Major spliceosome defects cause male infertility and are associated with nonobstructiveazoospermia in humans. Wu H, Sun L, Wen Y, Liu Y, Yu J, Mao F, Wang Y, Tong C, Guo X, Hu Z, Sha J,Liu M*, Xia L*.ProcNatlAcadSci USA.  2016 Apr 12;113(15):4134-9.

2. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M*, Matzuk MM*, Liu M*.Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5370-E5378.

3.An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice. Zhang Y, Guo R, Cui Y, Zhu Z, Zhang Y, Wu H, Zheng B, Yue Q, Bai S, Zeng W, Guo X, Zhou Z, Shen B, Zheng K, Liu M*, Ye L*, Sha J*. Cell Res. 2017 Nov;27(11):1392-1396.

4.FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W*, Liu M*.  Nucleic Acids Res. 2019 Nov 14. pii: gkz992. doi: 10.1093/nar/gkz992

5. Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Zhang X, Xiao Z, Zhang J, Xu C, Liu S, Cheng L, Zhou S, Zhao S, Zhang Y, Wu J, Wang Y*, Liu M*. Cell Rep. 2022 Nov 22;41(8):111683.

6. DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Zhou S, Yuan S, Zhang J, Meng L, Zhang X, Liu S, Lu G, Lin G, Liu M*, Tan YQ*. Signal Transduct Target Ther. 2023 Jan 10;8(1):26.

7. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M*, Gui M*, Wu J*. Cell. 2023 Jun 22;186(13):2897-2910

8.A metabolic hub in ciliary and flagellar motion. Xiao Z, Liu M*. Nat Struct Mol Biol. 2025 Aug;32(8):1327-1328

9. The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm. Zhi E, Bai H, Ren C, Dong Y, Zhang J, Xu Y, Tan C, Pan Y, Zhou L, Li P, Tan Y, Zhou Y, Meng L, Xu J, Zhang Y, Xu S, Ji Z, Zhao L, Jiang M, Li Z, Yao C, Zhou Y*, Wu J*, Yang X*, Liu S*, Liu M*. Nat Commun. 2025 Aug 23;16(1):7864.

10. A germline-specific vesicular structure licenses mRNA activation during spermiogenesis and is hijacked in gastric cancer. Liu M*, Wang Z, Li Y, Xie Q, Xiao Z, He X, Wang G, Gao Y, Zhang Y, Zheng L, Xia X, Chen L, Dong Y, Liu S, Zhang X, Xu C, Bian S, Yuan Y, Wu H, Cao Y*, Zhang J*, Hua R*, He X*. Sci Bull (Beijing). 2026 May 30;71(10):2574-2590 (cover story)

11. PUM1 and PUM2 promote translation of chromatin regulators to ensure mammalian spermatogenesis. Zang M, Liu S, Xie Z, Yang D, Wang K, Ding Y, Zhu T, Zhang S, Zhao T, Yao B*, Liu M*, Lin K*, Xu EY*. Sci Adv. 2026 Jul 17;12(29):eaed5708.