题    目：Epigenetic inheritance of acquired traits via sperm RNAs and

              RNA modifications

报告人：陈   琦  助理教授

              美国内华达大学里诺分校医学院 生理学和细胞生物学系

时    间：2018年11月8日（周四）上午10:00

地    点：学海楼B214室

主    持：王  强  教  授

陈琦，博士，助理教授，主要研究方向：精子tsRNAs作为父系表观遗传载体的功能以及相关调节机制。

近年来代表论文如下：

1. Liu Y, Chen Q#. 150 years of Darwin's theory on intercellular flow of hereditary information. Nature Reviews Molecular Cell Biology (2018) https://doi.org/10.1038/s41580-018-0072-4 [in press]

2. Shi J, Zhang Y, Zhou T#, Chen Q#. tsRNAs: the Swiss army knife for translational regulation. Trends in Biochemical Sciences（2018）Oct 5  https://doi.org/10.1016/j.tibs.2018.09.007

3. Chen Q*, Shi J*, Tao Y, Zernicka-Goetz M#. Tracing the origin of heterogeneity and symmetry breaking inthe early mammalian embryo. Nature Communications (2018) May 8;9(1):1819

4. Zhang Y*, Zhang X*, Shi J*, Tuorto F*, Li X*, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, YanM, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W,Lyko F, Zhang Y#, Zhou Q#, Duan E#, Chen Q#. Dnmt2-dependent intergenerational transmission of paternally acquired metabolic disorders via sperm RNAs. Nature Cell Biology (2018) May; 20(5):535-540.-Highlighted in: Nat Rev Endocrinol. 2018 Aug; 14(8):446-447.

5. Shi J#, Ko EA, Sanders KM, Chen Q#, Zhou T#. SPORTS1.0: a tool for annotating and profiling non-codingRNAs optimized for rRNA- and tRNA- derived small RNAs. Genomics Proteomics & Bioinformatics (2018)Apr; 16(2):144-151

6. Zhang Y, Shi J, Chen Q#. tsRNAs: new players in mammalian retrotransposon control. Cell Research. (2017)Nov; 27(11):1307-1308

7. Shi J, Zhang X, Liu Y, Chen Q#. Epigenetic information in gametes: gaming from before fertilization. Physicsof Life Reviews. (2017) Mar; 20:146-149.