华鹏博士，2015年毕业于英国谢菲尔德大学，之后任职于牛津大学Weatherall Institute从事生物医学相关研究工作。2021年加入南京医科大学任教授、博士生导师。迄今，华鹏博士主要成果包括研发新型3C方法（Micro-Capture C, MCC），并应用于研究基因组非编码区功能性，研究成果以第一、通讯作者身份于Nature、Blood等期刊上发表。

Researchgate: https://www.researchgate.net/profile/Peng-Hua-2

Seminars:https://mp.weixin.qq.com/s/jbN1ZvMqmS9rOdngaj19lQ

课题组研究方向为基于国家出生队列的子代健康影响因素研究，以及配子发生等相关方向的多组学研究：目前各种遗传性健康风险因素的评估、疾病的遗传性研究以及临床分子分型受限于数据精度，都还主要关注基因组编码区的基因突变。伴随着组学技术、基因编辑技术、体外培养技术等方面的迅速发展，通过多组学方法、生物信息学方法(深度神经网络)，并结合临床样本资源，系统解析人类基因组的调控机制，尤其是占到整个基因组>95%的非编码区基因如何调控关键基因的表达，不仅对于生殖生物学研究具有重要理论意义，同时将对我国妇幼健康和生殖医学研究产生积极而深远的影响。

科研经费及奖项：

江苏特聘教授（特别资助，2022）

国家重大人才工程A类（2022）

南京市2022年度留学人员科技创新项目（A类）

南京医科大学引进人才科研启动基金

代表性论文: 

1. Badat, M., Ejaz, A., Hua, P. et al. Direct correction of haemoglobin E β-thalassaemia using base editors. Nature Communications(2023). https://doi.org/10.1038/s41467-023-37604-8

2. Aljahani A, Hua P., et al. Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF. Nature Communications (2022). https://www.nature.com/articles/s41467-022-29696-5

3. Downes D, Cross A, Hua P., et al. Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. Nature Genetics (2021). 53, 1606–1615. https://www.nature.com/articles/s41588-021-00955-3

4. Hua P., et al. Defining  genome architecture at base pair resolution. Nature (2021). https://doi.org/10.1038/s41586-021-03639-4

5. Badat M, Hua P., et al., Base Editing Repairs the HbE Mutation Restoring the Production of Normal Globin Chains in Severe HbE/β-Thalassemia Patient Hematopoietic Stem Cells and Erythroid Cells. Blood, 2021. 138: p. 2935. https://ashpublications.org/blood/article/138/Supplement%201/2935/478923/Base-Editing-Repairs-the-HbE-Mutation-Restoring

6. Hua P., et al. The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes. Blood. 2020005357. https://ashpublications.org/blood/article/136/21/2410/461222/The-BET-inhibitor-CPI203-promotes-ex-vivo

7. Arroyo R, Georgiadis C, Hua P., et al. CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Communications Biology 3, 375 (2020) https://www.nature.com/articles/s42003-020-1097-8

8. Hua P., et al. Single cell analysis of bone marrow derived CD34+ cells from children with sickle cell disease and thalassemia. Blood 10/2019; 134(23). https://ashpublications.org/blood/article/134/23/2111/387151/Single-cell-analysis-of-bone-marrow-derived-CD34

9. Hua P., et al. Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion. Scientific Reports 03/2019; 9(1). https://www.nature.com/articles/s41598-019-41803-z

10. Hua P., et al. Molecular insights at the single cell level into the reprogramming of human hematopoietic stem cells during epigenetically modified ex vivo expansion. Blood 12/2017; 130:2425. https://ashpublications.org/blood/article/130/Supplement%201/2425/79945/Molecular-Insights-at-the-Single-Cell-Level-into?searchresult=1