叶岚教授,博士生导师

主要研究兴趣:

配子发生、表观遗传

乳腺癌发生机制

电话:025-86869509

E-maillanye@njmu.edu.cn

地址:南京医科大学学海楼


叶岚,教授,博士生导师,南京医科大学特聘教授。2009年于香港中文大学生物化学系博士学位,2009年-2013年美国宾夕法尼亚大学医学院糖尿病和代谢系博士后,主要从事研究表观遗传、代谢性疾病与雄性不育的关联性以及乳腺癌疾病发病机制及其治疗。2013年南京医科大学生殖医学国家重点实验室教授。研究成果在Science, Cell Res, Front Genet和J Clin Invest等国际杂志上发表。


承担项目

1.“江苏省高层次创新创业团队”核心成员,项目起止年月2016-2018,正在进行;

2.Rapamycin调控精子发生机制及临床相关性研究”,江苏省高校自然科学重大项目,批准号15KJA180006,项目起止年月2015.7-2018.6,项目负责人;

3.Rapamycin引起雄性不育和mTOR信号通路调控精子发生的分子机制研究”,国家自然科学基金面上项目,批准号81471502,项目起止年月2015.1-2018.12,项目负责人;


代表性论文(5篇)

1. Yue Zhang, Rui Guo, Yiqiang Cui, Zhiping Zhu, Yingwen Zhang, Hao Wu, Bo Zheng, Qiuling Yue, Shun Bai, Wentao Zeng, Xuejiang Guo,Zuomin Zhou, Bin Shen, Ke Zheng, Mingxi Liu#, Lan Ye#, Jiahao Sha#. An essential role for PNLDC1 in piRNA 3′ end trimming and male fertility in mice. Cell Res, 2017, 27(11): cr2017125.

2. Mengneng Xiong, Zhiping Zhu, Suwen Tian, Ruping Zhu,Shun Bai, Kaiqiang Fu, James G. Davis, Zheng Sun,Joseph A. Baur, Ke Zheng, Lan Ye#. Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. May 2017.   

3. Dudley W Lamming#, Lan Ye#, PekkaKatajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima, David A Guertin, David M Sabatini, Joseph A Baur: Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science, Mar 2012, 335(6076): 1638-43.

4. Dudley W. Lamming, Lan Ye, David M. Sabatini, and Joseph A. Baur: Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest, 2013 Mar, 123(3):980-9.

5. Lan Ye#, Wai M. Gho, Franky L. Chan, Shiuan Chen, Lai K. Leung. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.

Int J Cancer, Mar 2009, 124(5):1028-36.